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AquariumSmiths Dewormer and No-Planaria is an anthelmintic (anti-worm) medication that is safe to use in aquaria and effective against many internal parasites, especially nematodes, when used in appropriate dosages.
It does not harm the bio-filter, plants, invertebrates, or uninfected fish. As an added benefit, it boosts the immune competence of fish.
The active ingredient is absorbed through the gut, can also be absorbed through the skin, and is distributed throughout the body. It affects the neurotransmitters and paralyzes the worm (spastic paralysis). The fish then passes the inactive worms. Good gravel vacuuming is advised after treatment to remove the paralyzed (but still live) worms. It is not ovicidal, which means it will not affect eggs already present, but it will affect the larval stage of the worm. To ensure complete eradication of the parasite treat again after remaining eggs have hatched.
Nematodes (roundworms) and Planaria in particular are well-controlled by this treatment. Nematodes such as Capillaria, Eustronggylides, Camallanus, and Contracaecum are common among many fish species.
Hobbyists have been using it for years now and there are few reports of negative effects on fish. At higher dosages than recommended, there have been some reports of cloudy water at initial treatment and very few reports of rapid respiration or stress-related behavior in fish.